Have you thought about setting an RPG in an inhospitable such as a frozen world, dark planet or even in the ocean?
"This is not how the world ends" is the prophecy that brings some hope to the snowy realm of Nyth.
It was a midsummer day when winter ambushed the world. Lakes turned to ice, and even the sun grew more distant. Crops failed, and wars over resources erupted. Temples were overrun by the hungry, but the gods were silent.