D&D 5e's next official setting is Spelljammer. That's a popular old setting being revisited for 5e. You can't call it sci-fi; there's not so much science as fantasy, and perhaps space opera is better than a genre.
Unearthed Arcana: Giant Options is a new and official D&D playtest that focuses on giants.
After studying your feedback, we've revised the kender race, the Knight of Solamnia and Mage of High Sorcery backgrounds, and several feats for characters from the world of Krynn.
Typically, Wizards of the Coast don't playtest things for a laugh. As a rule of thumb, a playtest generally means the D&D publisher is seriously considering entering them into the world of 5e.
The Travelers of the Multiverse offers up six new PC races, some from Spelljammer.
There is may well enough time for the playtest to complete, for results to come in, the book finished and sent to the printers. If, indeed, that's the plan.
Available from today are new Draconic options. The free PDF includes three alternatives to the dragonborn race, a new look at kobolds, feats and then spells.
D&D have released an Unearthed Arcana of Feywild races.
This racebook follows Tasha's Cauldron of Everything and lacks Ability Score increase trait, Language and Alignment. You can be a good Dhampir if it makes narrative sense.
These new rules add character options for Warlocks and Bards, and both have a spooky theme.